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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
32.12
Human Site:
Y928
Identified Species:
50.48
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
Y928
Q
E
L
G
Q
N
Q
Y
A
V
S
G
E
I
F
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
Y936
Q
E
L
G
Q
N
Q
Y
A
V
S
G
E
I
F
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
Y922
Q
E
L
G
Q
N
Q
Y
A
V
S
G
E
I
F
Dog
Lupus familis
XP_534241
2041
231068
Y1346
Q
E
L
G
Q
N
Q
Y
A
V
S
G
E
I
F
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
Y916
Q
E
L
G
Q
N
Q
Y
A
V
S
G
E
I
F
Rat
Rattus norvegicus
P41516
1526
173202
P883
R
L
L
D
G
E
E
P
L
P
M
L
P
S
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
Y1231
Q
E
L
G
Q
N
Q
Y
A
V
S
G
E
I
F
Chicken
Gallus gallus
O42131
1627
183228
Y933
Q
E
L
G
Q
N
Q
Y
V
V
S
G
E
I
F
Frog
Xenopus laevis
NP_001082502
1579
178601
F905
Q
E
L
G
P
N
Q
F
I
L
N
G
E
V
S
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
Y927
H
E
L
G
Q
N
Q
Y
L
V
S
G
E
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
P804
I
Y
H
P
L
D
D
P
L
L
D
Y
Q
V
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
C877
R
I
E
P
E
W
Y
C
P
I
I
P
M
V
L
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
N805
A
Q
N
F
V
G
S
N
N
L
N
L
L
Q
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
Y830
Q
R
I
E
P
T
W
Y
M
P
I
I
P
T
V
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
T785
A
A
A
R
Y
I
Y
T
E
L
N
K
L
T
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
100
93.3
53.3
73.3
N.A.
0
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
100
93.3
80
80
N.A.
26.6
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
7
7
0
0
0
0
0
40
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
7
7
0
0
0
7
0
0
0
7
% D
% Glu:
0
60
7
7
7
7
7
0
7
0
0
0
60
0
0
% E
% Phe:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
47
% F
% Gly:
0
0
0
60
7
7
0
0
0
0
0
60
0
0
0
% G
% His:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
7
7
0
0
7
0
0
7
7
14
7
0
47
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% K
% Leu:
0
7
67
0
7
0
0
0
20
27
0
14
14
0
7
% L
% Met:
0
0
0
0
0
0
0
0
7
0
7
0
7
0
0
% M
% Asn:
0
0
7
0
0
60
0
7
7
0
20
0
0
0
0
% N
% Pro:
0
0
0
14
14
0
0
14
7
14
0
7
14
0
7
% P
% Gln:
60
7
0
0
54
0
60
0
0
0
0
0
7
7
0
% Q
% Arg:
14
7
0
7
0
0
0
0
0
0
0
0
0
0
7
% R
% Ser:
0
0
0
0
0
0
7
0
0
0
54
0
0
7
14
% S
% Thr:
0
0
0
0
0
7
0
7
0
0
0
0
0
14
0
% T
% Val:
0
0
0
0
7
0
0
0
7
54
0
0
0
27
7
% V
% Trp:
0
0
0
0
0
7
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
7
0
14
60
0
0
0
7
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _